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KMID : 0897520060110010023
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Journal of Korean Association of Social Psychiatry
2006 Volume.11 No. 1 p.23 ~ p.29
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The Comparison of Haloperidol, Risperidone, and Olanzapine in the Prevention of Relapse in Schizophrenic Patients
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Lee Jong-Il
Han Hee-Jong
Yoon Hae-Joo
Chung Eun-Kee
Chang Dong-Won
Kim Seong-Taek
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Abstract
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Objective： Prevention of relapse is a major goal of maintenance treatment in patients with schizophrenia. This study examined the treatment response of haloperidol, risperidone, and olanzapine by the way of relapse rates for 3 years in schizophrenic patients.
Methods： Authors examined medical records of subjects who have been taken medications at adult outpatient’s clinic. Data were analyzed from three groups of haloperidol(N=305), risperidone(N=179), and olanzapine(N=40) treatment. All of subjects have been in stable condition. We analyzed data by relapse rates and Kaplan-Meier survival analysis for 3 years.
Results： Of the 305 patients to haloperidol, the 179 patients to risperidone, and the 40 patients to olanzapine who remained in the analysis of relapse, 43.9%, 31.3%, and 37.5%, respectively, discontinued treatment for reasons other than relapse. The Admission rate due to relapse was showed 38.0%, 18.7%, and 36.0%, respectively. Patients in the risperidone group had a lower admission rate than the haloperidol group(χ2=5.419, df=1, p=0.02). In Kaplan-Meier survival analysis, the risk of relapse was showed 65.1% in haloperidol group, 44.1% in risperidone group, and 60.0% in olanzapine group. Survival rate was 34.9%, 55.9%, and 40.0%, respectively. Patients in the risperidone group had a higher survival rate than the haloperidol group(log-rank 18.29, df=1, p=0.00).
Conclusion： Adult outpatients with clinically stable schizophrenia have a lower risk of relapse and a higher survival rate if they are treated with risperidone than if they are treated with haloperidol.
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KEYWORD
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Schizophrenia, Haloperidol, Risperidone, Olanzapine, Relapse
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